While the acne-preventing principles adopted by Proactiv are used by most acne treatment systems these days, other plans may have slightly different ingredients. This means that if Proactiv doesn't work for you, there's still a good chance that another series of cleansers, toners, and medicated lotions could help clear up your acne. As mentioned above, the Proactiv products all contain fragrance, which can be irritating, and the toner includes color additives, which may be unnecessary. I'm sure there are other product lines that are more natural. Also, benzoyl peroxide is not for everyone, no matter what the concentration, so if your skin feels irritated maybe try a line using a different active ingredient. If you haven't tried Proactiv yet, it does have a 60-day money-back guarantee, so it's probably worth considering. In the very least, it gets you into a good skin care regimen, which is a great habit to acquire. The best of luck to us all!!